Microwave-assisted asymmetric ring opening of meso-epoxides with aromatic amines catalyzed by a Ti-S-(−)-BINOL complex

R I, Kureshy and Surendra, Singh and N H, Khan and S H R , Abdi and Santosh , Agrawal and Vishal J, Mayani and R V , Jasra (2006) Microwave-assisted asymmetric ring opening of meso-epoxides with aromatic amines catalyzed by a Ti-S-(−)-BINOL complex. Tetrahedron Letters , 47 (30). pp. 5277-5279.

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Official URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THS-4K5SSY8-6&_user=518931&_coverDate=07%2F24%2F2006&_alid=589647082&_rdoc=5&_fmt=full&_orig=search&_cdi=5290&_sort=d&_docanchor=&view=c&_ct=28&_acct=C000025838&_version=1&_urlVersion=0&_userid=51

Abstract

Catalytic asymmetric ring opening of cyclohexene oxide and meso-stilbene oxide with anilines was catalyzed by a Ti-(S)-(−)-BINOL complex to afford β-amino alcohols in high yield (up to 95%) and good enantioselectivities (ee up to 55%) under microwave irradiation. The reaction using a microwave was found to be 10 times faster than traditional oil-bath heating with retention of enantioselectivity.

Item Type:	Article
Subjects:	Science > Chemistry
ID Code:	923
Deposited By:	Prof Balasubramanian Viswanathan
Deposited On:	16 Jun 2007 15:07
Last Modified:	16 Jun 2007 15:07

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