Simultaneous production of chirally enriched epoxides and 1,2-diols from racemic epoxides via hydrolytic kinetic resolution (HKR)

R I, Kureshy and N H, Khan and S.H.R., Abdi and Sunil T, Patel and R V , Jasra (2002) Simultaneous production of chirally enriched epoxides and 1,2-diols from racemic epoxides via hydrolytic kinetic resolution (HKR). Journal of Molecular Catalysis A: Chemical , 179 (1-2). pp. 73-77.

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Abstract

Hydrolytic kinetic resolution (HKR) of racemic epichlorohydrin, styrene oxide and propene oxide was investigated using dimeric homochiral Co(III) Schiff base complex derived from mono-tartrate salt of (1R,2R)-(−)-cyclohexane diamine with 3,5-di-tert-butyl salicylaldehyde and 5,5-methylene-di-3-tert-butyl salicylaldehyde with an objective to get high efficiency and recycling capability of the catalyst. Excellent conversions to enantiomerically pure epoxide and diols along with high chiral induction were obtained in all the cases. With a loading <0.3 mol% of the catalyst, the system works well up to three cycles without any loss in activity and selectivity.

Item Type:	Article
Uncontrolled Keywords:	Hydrolytic kinetic resolution; Racemic; Co(III); Schiff base; Epoxide; Diol
Subjects:	Science > Chemistry
ID Code:	909
Deposited By:	Prof Balasubramanian Viswanathan
Deposited On:	14 Jun 2007 09:34
Last Modified:	14 Jun 2007 09:34

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