Asymmetric synthesis of amines by the reductive amination of ketones using (+) and (−) norephedrine followed by periodate oxidation.

R, Sreekumar and C N, Pillai (1993) Asymmetric synthesis of amines by the reductive amination of ketones using (+) and (−) norephedrine followed by periodate oxidation. Tetrahedron: Asymmetry , 4 (9). pp. 2095-2100.

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Abstract

A new route for the synthesis of aralkyl primary amines is reported, where the commercially available (+) or (−) norephedrine is condensed with aralkyl ketones followed by hydrogenation of the Schiff base using platinum catalyst. The chiral β-aminoalcohols thus obtained were oxidized by periodate to yield the aralkyl primary amines in 54–66% enantiomeric excess.

Item Type:	Article
Subjects:	Science > Chemistry
ID Code:	859
Deposited By:	Prof Balasubramanian Viswanathan
Deposited On:	11 Jun 2007 09:29
Last Modified:	11 Jun 2007 09:29

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