Dhanashri P, Sawant and S.B., Halligudi (2004) Liquid phase acetylation of thioanisole with acetic anhydride to 4-(methylthio) acetophenone (4-MTAP) using H-beta catalyst. Catalysis Communications , 5 . pp. 659-663.
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Abstract
Acetylation of thioanisole (TA) with acetic anhydride (AA) to give p-(methylthio) acetophenone (4-MTAP) has been investigated using different solid acid catalysts such as H-Y, H-ZSM-5, H-mordenite and H-beta in liquid phase conditions. The reaction is studied in the temperature range 80–180 C in a pressure reactor under nitrogen atmosphere. Among the catalysts tested, H-beta is found to be more active and shape selective than other zeolite catalysts. The conversion of TA (32 mol%) with a turnover frequency, TOF, 30.6 (104 s1 mol1 Al) gave exclusively 4-MTAP (99.9%) and the other o-(methylthio) acetophenone (2-MTAP) over H-beta at 150 C after 2 h. Acidity and structural features of zeolites play an important role in the conversion and product distribution in acetylation of TA. The effect of AA/TA molar ratio, catalyst oncentration and reaction temperature have been optimized to get higher conversion of TA and product selectivity. Efficient utility of AA has been established in the reaction. H-beta catalyst has been reused in few cycles after regeneration by washing with ethyl acetate followed by calcination at 500 C for 4 h without loss in its activity.
Item Type: | Article |
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Subjects: | Science > Chemistry |
ID Code: | 305 |
Deposited By: | INVALID USER |
Deposited On: | 02 Mar 2007 04:01 |
Last Modified: | 02 Mar 2007 04:01 |
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