Catalysis Database

Synthesis of Dihydropyrimidinones Using Large Pore Zeolites

Sunil R, Mistry and Rikesh S, Joshi and Suban K, Sahoo and Kalpana C, Maheria (2011) Synthesis of Dihydropyrimidinones Using Large Pore Zeolites. Catalysis letters . (In Press)

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Abstract

A series of dihydropyrimidin-2(1H)-one (DHPM) belongs to one of the important class of therapeutic and pharmacological active compound, were synthesized through the multicomponent reactions (MCRs) of aldehydes, ethyl acetoacetate and urea, followed by the heterogeneous catalyzed Biginelli reaction. In the present endeavour, medium (ZSM-5) and large pore zeolites (Y, BEA and MOR) as well as dealuminated zeolites BEA, were studied as catalysts. An excellent activity for DHPMs synthesis is achieved by optimizing accessibility of the reactants to the active sites and the surface polarity of zeolite catalysts.Moreover, themechanism of Biginelli reaction was studied by means of GAUSSVIEW energy calculations of adsorbed acylimine intermediate on zeolite by using the density functional method (DFT).

Item Type:Article
Subjects:Q Science > QD Chemistry
ID Code:1970
Deposited By: Prof Balasubramanian Viswanathan
Deposited On:12 Jun 2011 00:00
Last Modified:21 Apr 2019 04:22

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